| Date | Location | Result | |
| Nov 05, 2010 | Owensboro, KY | UIS 3, Kentucky Wesleyan 2 (25-19,19-25,19-25,25-17,15-7) | Box score |
| Nov 06, 2010 | Evansville, IN | Southern Indiana 3, UIS 0 (25-12,25-19,25-22) | Box score |
| Oct 30, 2010 | Springfield, Ill. | Bellarmine 3, UIS 0 (25-17,25-23,25-16) | Box score |
| Oct 29, 2010 | Springfield,IL | Northern Kentucky 3, UIS 0 (25-18,25-23,25-20) | Box score |
| Oct 26, 2010 | Springfield, Ill. | UIS 3, Robert Morris 0 (25-13,25-12,25-11) | Box score |
| Oct 23, 2010 | Springfield, Ill. | Drury 3, UIS 1 (25-23,25-18,24-26,25-13) | Box score |
| Oct 22, 2010 | Springfield, Ill. | Rockhurst 3, UIS 0 (25-20,27-25,25-18) | Box score |
| Oct 20, 2010 | Springfield, Ill. | UIS 3, Missouri Baptist 0 (25-19,25-18,25-16) | Box score |
| Oct 16, 2010 | Aurora, Ill. | Lake Superior State 3, UIS 0 (25-19,25-17,25-19) | Box score |
| Oct 16, 2010 | Aurora, IL | Saginaw Valley State 3, UIS 0 (25-20,25-15,25-16) | Box score |
| Oct 15, 2010 | Aurora, IL | UIS 3, Lake Erie 1 (25-23,22-25,25-22,25-22) | Box score |
| Oct 08, 2010 | St. Louis, MO | Maryville University 3, UIS 0 (25-20,25-23,25-15) | Box score |
| Oct 07, 2010 | Springfield, Ill. | UIS 3, Quincy 0 (25-19,25-16,25-23) | Box score |
| Oct 05,2010 | Springfield, Ill. | UIS 3, Robert Morris-Peoria 0 (25-11,25-8,25-13) | Box score |
| Oct 02, 2010 | Springfield, Ill. | UINDY 3, UIS 0 (25-12,25-21,25-21) | Box score |
| Oct 01, 2010 | Springfield, Ill. | SJC 3, UIS 2 (23-25,25-19,19-25,25-14,18-16) | Box score |
| Sep 28, 2010 | Springfield, Ill. | UIS 3, Benedictine 0 (25-15,25-13,25-22) | Box score |
| Sep 25, 2010 | Romeoville, IL | Lewis 3, UIS 0 (25-22,25-20,25-13) | Box score |
| Sep 24, 2010 | UWP Somers, Wis. | UW-Parkside 3, UIS 0 (25-13,25-20,25-23) | Box score |
| Sep 18, 2010 | St. Louis, MO | Missouri-St. Louis 3, UIS 0 (25-15,25-10,25-4) | Box score |
| Sep 17, 2010 | Rolla, MO | Missouri S&T 3, UIS 0 (25-12,25-15,25-19) | Box score |
| Sep 14, 2010 | Lincoln, Ill. | UIS 3, Lincoln Christian 0 (25-17,25-13,25-19) | Box score |
| Sep 11, 2010 | St. Louis, MO | Washburn 3, UIS 0 (25-13,25-12,25-18) | Box score |
| Sep 11, 2010 | St. Louis, MO | Harding 3, UIS 0 (25-16,25-11,25-18) | Box score |
| Sep 10, 2010 | St. Louis, MO | Truman State 3, UIS 0 (25-18,25-22,25-19) | Box score |
| Sep 10, 2010 | St. Louis, MO | UIS 3, Minnesota-Crookston 0 (25-23,27-25,25-21) | Box score |
| Sep 04, 2010 | Memphis, TN | UIS 3, Stillman 0 (25-21,25-19,25-8) | Box score |
| Sep 04, 2010 | Memphis, TN | Missouri Western St. 3, UIS 1 (21-25,25-10,25-17,25-14) | Box score |
| Sep 03, 2010 | Memphis, TN | Christian Brothers 3, UIS 0 (25-18,25-23,25-20) | Box score |
| Sep 03, 2010 | Memphis, TN | Ouachita Baptist 3, UIS 1 (18-25,26-24,25-19,27-25) | Box score |