| Date | Location | Result | |
| 11/19/21 | East Peoria, Ill. | Missouri-St. Louis 3, Illinois Springfield 0 (25-21,25-12,25-10) | Box score |
| 11/13/21 | Lebanon, Ill. | Illinois Springfield 3, McKendree 0 (25-16,25-17,25-16) | Box score |
| 11/12/21 | Indianapolis, Ind. | Illinois Springfield 3, Indianapolis 0 (25-22,25-17,25-23) | Box score |
| 11/09/21 | Evansville, Ind. | Southern Indiana 3, Illinois Springfield 0 (25-16,25-22,25-22) | Box score |
| 11/06/21 | Kirksville, Mo. | Illinois Springfield 3, Truman 0 (25-14,25-19,25-22) | Box score |
| 11/05/21 | Saint Charles, Mo. | Illinois Springfield 3, Lindenwood (MO) 1 (25-22,25-23,26-28,28-26) | Box score |
| 11/02/21 | Springfield, Ill. | Lewis 3, Illinois Springfield 1 (25-11,21-25,25-23,25-19) | Box score |
| 10/30/21 | Springfield, Ill. | Illinois Springfield 3, Southwest Baptist 0 (25-17,28-26,25-8) | Box score |
| 10/29/21 | Springfield, Ill. | Illinois Springfield 3, Drury 1 (25-23,25-13,21-25,25-23) | Box score |
| 10/22/21 | Springfield, Ill. | Southern Ind. 3, Illinois Springfield 2 (23-25,25-21,25-16,23-25,15-12) | Box score |
| 10/16/21 | Hammond, Ind. | Illinois Springfield 3, Purdue Northwest 0 (25-19,25-20,25-23) | Box score |
| 10/16/21 | Hammond, Ind. | Illinois Springfield 3, Ky. Wesleyan 0 (25-21,25-18,25-22) | Box score |
| 10/15/21 | Hammond, Ind. | Cedarville 3, Illinois Springfield 2 (25-21,16-25,23-25,25-18,15-12) | Box score |
| 10/09/21 | Liberty, Mo. | William Jewell 3, Illinois Springfield 0 (25-10,25-17,25-20) | Box score |
| 10/08/21 | Rolla, Mo. | Missouri S&T 3, Illinois Springfield 2 (25-23,25-20,23-25,21-25,15-10) | Box score |
| 10/05/21 | Romeoville, Ill. | Lewis 3, Illinois Springfield 2 (18-25,25-21,22-25,25-12,15-12) | Box score |
| 10/02/21 | Springfield, Ill. | Illinois Springfield 3, Maryville 0 (25-12,25-18,25-12) | Box score |
| 10/01/21 | Springfield, Ill. | Illinois Springfield 3, Quincy 1 (25-23,25-11,17-25,25-21) | Box score |
| 09/25/21 | Springfield, Ill. | Illinois Springfield 3, McKendree 1 (19-25,28-26,25-23,25-21) | Box score |
| 09/24/21 | Springfield, Ill. | Illinois Springfield 3, Indianapolis 1 (21-25,25-23,25-22,25-22) | Box score |
| 09/18/21 | Kansas City, Mo. | Rockhurst 3, Illinois Springfield 2 (25-21,19-25,24-26,25-16,15-9) | Box score |
| 09/16/21 | Springfield, Ill. | Mo.-St. Louis 3, Illinois Springfield 1 (21-25,25-21,25-16,25-20) | Box score |
| 09/11/21 | Springfield, Ill. | Michigan Tech 3, Illinois Springfield 0 (25-21,25-20,25-13) | Box score |
| 09/11/21 | Springfield, Ill. | Grand Valley St. 3, Illinois Springfield 0 (25-23,25-20,25-13) | Box score |
| 09/10/21 | Springfield, Ill. | Upper Iowa 3, Illinois Springfield 1 (25-17,25-15,20-25,25-18) | Box score |
| 09/10/21 | Springfield, Ill. | Illinois Springfield 3, Lake Erie 0 (25-20,25-21,25-23) | Box score |
| 09/04/21 | Tampa, Fla. | Augustana (S.D.) 3, Illinois Springfield 1 (25-23,20-25,25-22,25-23) | Box score |
| 09/04/21 | Tampa, Fla. | Northwest Mo. St. 3, Illinois Springfield 0 (25-16,26-24,25-21) | Box score |
| 09/03/21 | Tampa, Fla. | Tampa 3, Illinois Springfield 0 (25-15,25-20,27-25) | Box score |
| 09/03/21 | Tampa, Fla. | Illinois Springfield 3, Ashland 2 (23-25,21-25,25-22,25-22,15-13) | Box score |