| Date | Location | Result | |
| 02/28/22 | Evansville, IN | Southern Indiana 81, Illinois Springfield 52 | Box score |
| 02/26/22 | Springfield, MO | Drury 62, Illinois Springfield 61 | Box score |
| 02/24/22 | Rolla, MO | Illinois Springfield 76, Missouri S&T 58 | Box score |
| 02/19/22 | Springfield, IL | Illinois Springfield 66, Rockhurst 63 | Box score |
| 02/17/22 | Springfield, IL | Southwest Baptist 75, Illinois Springfield 57 | Box score |
| 02/12/22 | Kirksville, MO | Truman 78, Illinois Springfield 72 | Box score |
| 02/10/22 | Liberty, MO | Illinois Springfield 64, William Jewell 53 | Box score |
| 02/07/22 | Romeoville, IL | Lewis 71, Illinois Springfield 63 | Box score |
| 02/03/22 | Springfield, IL | Quincy 80, Illinois Springfield 74 | Box score |
| 01/31/22 | Kansas City, MO | Rockhurst 73, Illinois Springfield 64 | Box score |
| 01/29/22 | Springfield, IL | Indianapolis 62, Illinois Springfield 50 | Box score |
| 01/27/22 | Springfield, IL | Lewis 83, Illinois Springfield 63 | Box score |
| 01/22/22 | Lebanon, IL | McKendree 77, Illinois Springfield 69 | Box score |
| 01/20/22 | Evansville, IN | Southern Indiana 66, Illinois Springfield 39 | Box score |
| 01/17/22 | Springfield, IL | Illinois Springfield 79, Maryville 71 (OT) | Box score |
| 01/15/22 | Springfield, IL | Illinois Springfield 68, Missouri-St. Louis 64 | Box score |
| 01/13/22 | Saint Charles, MO | Illinois Springfield 98, Lindenwood 66 | Box score |
| 01/06/22 | Springfield, IL | Illinois Springfield 80, Drury 76 | Box score |
| 12/30/21 | Springfield, IL | Illinois Springfield 68, Culver-Stockton 65 | Box score |
| 12/19/21 | Springfield, IL | Illinois Springfield 78, Purdue Northwest 68 (OT) | Box score |
| 12/11/21 | Springfield, IL | Illinois Springfield 64, Hannibal-LaGrange 42 | Box score |
| 12/04/21 | Indianapolis, IN | Indianapolis 63, Illinois Springfield 59 | Box score |
| 12/02/21 | Springfield, IL | Southern Indiana 64, Illinois Springfield 52 | Box score |
| 11/29/21 | Springfield, IL | McKendree 51, Illinois Springfield 47 | Box score |
| 11/24/21 | Indianapolis, IN | Illinois Springfield 94, Ohio Valley 57 | Box score |
| 11/23/21 | Indianapolis, IN | Northwood 79, Illinois Springfield 71 | Box score |
| 11/18/21 | Springfield, IL | Illinois Springfield 68, Eureka 39 | Box score |
| 11/13/21 | St. Charles, MO | Parkside 92, Illinois Springfield 79 | Box score |
| 11/12/21 | Kentucky Wesleyan 84, Illinois Springfield 76 | Box score |