| Date | Location | Result | |
| 04/10/21 | Springfield, Ill. | Indianapolis 3, Illinois Springfield 1 (23-25,25-20,25-21,28-26) | Box score |
| 04/09/21 | Springfield, Ill. | Southern Indiana 3, Illinois Springfield 1 (25-18,25-18,19-25,25-18) | Box score |
| 04/03/21 | Lebanon, Ill. | McKendree 3, Illinois Springfield 0 (25-22,26-24,25-22) | Box score |
| 03/27/21 | Romeoville, Ill. | Lewis 3, Illinois Springfield 0 (25-16,25-20,25-13) | Box score |
| 03/20/21 | St. Louis, Mo. | William Jewell 3, Illinois Springfield 0 (25-23,25-20,25-22) | Box score |
| 03/20/21 | St. Louis, Mo. | Missouri-St. Louis 3, Illinois Springfield 0 (25-17,25-14,25-20) | Box score |
| 03/13/21 | Springfield, Ill. | Illinois Springfield 3, Maryville 0 (25-17,25-18,25-18) | Box score |
| 03/13/21 | Springfield, Ill. | Rockhurst 3, Illinois Springfield 0 (25-18,25-17,25-21) | Box score |
| 03/09/21 | Springfield, Ill. | Truman 3, Illinois Springfield 0 (30-28,25-18,25-22) | Box score |
| 03/05/21 | Springfield, Mo. | Lindenwood 3, Illinois Springfield 0 (25-16,25-15,25-15) | Box score |
| 03/05/21 | Springfield, Mo. | Drury 3, Illinois Springfield 0 (25-19,25-19,25-19) | Box score |
| 02/28/21 | Quincy, Ill. | Quincy 3, Illinois Springfield 0 (25-20,25-18,25-19) | Box score |
| 02/28/21 | Quincy, Ill. | Illinois Springfield 3, Southwest Baptist 0 (25-17,25-22,25-19) | Box score |
| 02/20/21 | Springfield, Ill. | Truman 3, Illinois Springfield 1 (25-19,18-25,25-21,25-17) | Box score |
| 02/20/21 | Springfield, Ill. | Missouri S&T 3, Illinois Springfield 0 (25-16,25-16,25-19) | Box score |
| 02/12/21 | Springfield, Ill. | Lewis 3, Illinois Springfield 2 (25-16,28-30,25-16,22-25,15-9) | Box score |
| 02/05/21 | Springfield, Ill. | Illinois Springfield 3, McKendree 0 (25-15,25-18,25-18) | Box score |
| 01/30/21 | Evansville, Ind. | Southern Indiana 3, Illinois Springfield 0 (25-22,26-24,25-14) | Box score |
| 01/29/21 | Indianapolis, Ind. | Indianapolis 3, Illinois Springfield 2 (25-16,21-25,14-25,29-27,15-13) | Box score |